Author

William J. Hutchison

The University of MelbourneORCID 0009-0001-6242-4269Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:dimensionality reduction· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:batch correction / integration· 1 Research Focus:benchmarking· 1 Research Focus:clustering· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Anthony T. PapenfussiD· 3 shared Stefano MangiolaiD· 3 shared Martin T. MorganiD· 2 shared Yingnan GaoiD· 2 shared Abdullah Al NahidiD· 1 shared Ajithkumar VasanthakumariD· 1 shared Axel KalliesiD· 1 shared Belinda Jane YeoiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersBioinformatics

Anthony T. PapenfussORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 23, 2026

ICOS blockade alleviates immune suppression in breast tumor microenvironment

Shalini Guleria, Chamikara Liyanage, William J. Hutchison…·Bhupinder Pal

This study shows that blocking ICOS reduces immune suppression in breast tumors by altering Treg and CD8 T cell dynamics, enhancing anti-tumor immunity.

DOI 10.64898/2026.10.22.760908

mousespatial transcriptomics

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BioinformaticsbioRxivPreprintMay 5, 2026

cellNexus: Quality control, annotation, aggregation and analytical layers for the Human Cell Atlas data

Mengyuan Shen, Yingnan Gao, Ning Liu…·Stefano Mangiola

cellNexus enhances Human Cell Atlas data by adding quality control, metadata, normalization, and analysis layers to enable multi-study analyses and large-scale biological discovery.

1 citation

humanscRNA-seq

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BioinformaticsNature MethodsPeer-reviewedJun 14, 2024

The tidyomics ecosystem: Enhancing omic data analyses

William J. Hutchison, Timothy Keyes, Helena Lucia Crowell…·Stefano Mangiola

The paper introduces tidyomics, an ecosystem bridging Bioconductor and tidy R to streamline omic analysis using data from the Human Cell Atlas.

29 citationstop 2%

humanbulk RNA-seq

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