Bhupinder Pal

Single-cell RNA-seq of amniotic fluid provides unique insight into fetal development

This study uses scRNA-seq on amniotic fluid to create a cell atlas of healthy fetal cells, revealing gestational age-related changes in cell composition and gene expression.

ICOS blockade alleviates immune suppression in breast tumor microenvironment

This study shows that blocking ICOS reduces immune suppression in breast tumors by altering Treg and CD8 T cell dynamics, enhancing anti-tumor immunity.

An MLL-Independent Function of Menin Promotes Resistance to MAPK-Targeted Therapy

This study identifies Menin's MLL-independent role in promoting resistance to MAPK-targeted therapy in BRAF-mutant colorectal cancer.

LeGO-Teknik reveals that the neurogenesis pathway is a clone-specific hallmark of brain metastasis in breast cancer

The paper identifies neurogenesis-related gene expression as a clone-specific hallmark of brain metastasis in breast cancer using a new optical barcoding tool.

A TAK1Cytokine Toxicity Checkpoint Controls Anti-Cancer Immunity

This study identifies TAK1 as a cancer-intrinsic checkpoint that limits CD8+ T cell-mediated anti-cancer immunity by suppressing TNF and IFNγ-induced apoptosis, and shows that targeting TAK1 enhances anti-tumor responses.

R code and downstream analysis objects for the scRNA-seq atlas of human breast spanning normal, preneoplastic and tumorigenic states

The paper provides R code and processed data objects to reproduce analyses of a scRNA-seq atlas of human breast tissue across normal, preneoplastic, and tumorigenic states.

ID4 represses myoepithelial differentiation of mammary stem cells through its interaction with HEB

This study identifies ID4 as a repressor of myoepithelial differentiation in mammary stem cells through its interaction with HEB, using integrated transcriptomic, proteomic, and ChIP-sequencing data.