Author

Sumedha Negi

The University of QueenslandORCID 0009-0001-7523-3576Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Developmental Biology· 1 Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:differential expression· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:GWAS / association mapping· 2 Research Focus:benchmarking· 1 Approach:experimental assay· 1

Frequent Co-Authors

Nathan J. PalpantiD· 4 shared Sophie SheniD· 4 shared Woo Jun ShimiD· 4 shared Chris Siu Yeung ChowiD· 3 shared Yuanzhao CaoiD· 3 shared Amy D. HannaiD· 2 shared Clarissa TaniD· 2 shared Dalia MizikovskyiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersSystems Biology

Nathan J. PalpantORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Systems BiologybioRxivPreprintMar 31, 2026

Protocol-dependent cardiomyocyte states determine disease modelling capacity of human iPSCs

Sophie Shen, Clarissa Tan, Yuanzhao Cao…·Nathan J. Palpant

This study compares sixteen iPSC-CM differentiation protocols to identify how protocol-dependent cell states affect disease modeling capacity for cardiovascular conditions.

DOI 10.64898/2026.03.29.715135

humanscRNA-seq

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Cell BiologybioRxivPreprintMar 15, 2026

Hierarchical control of cardiomyocyte maturation and ischaemia sensitivity by metabolic culture conditions

Yuanzhao Cao, Chris Siu Yeung Chow, Sumedha Negi…·Nathan J. Palpant

This study shows how metabolic culture conditions affect cardiomyocyte maturation and sensitivity to ischaemia-reperfusion injury using hiPSC-CMs.

DOI 10.64898/2026.03.12.711459

humanbulk RNA-seq

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Developmental BiologybioRxivPreprintSep 4, 2024

A community-oriented, data-driven resource to improve protocol design for cardiac modelling from human pluripotent stem cells

Chris Siu Yeung Chow, Sophie Shen, Amy Hanna…·Nathan J. Palpant

The paper develops a resource to improve cardiac modelling protocols using hPSC-CMs by analyzing decades of research data and providing tools for protocol benchmarking.

2 citations

humanstatistical model

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GenomicsbioRxivPreprintOct 12, 2022

A pluripotent stem cell atlas of multilineage differentiation reveals TMEM88 as a developmental regulator of mammalian blood pressure

Sophie Shen, Tessa R. Werner, Samuel W. Lukowski…·Nathan J. Palpant

The paper creates an iPSC differentiation atlas and identifies TMEM88 as a regulator of mesendodermal development and blood pressure.

2 citations

humanbulk RNA-seq

𝕏 PostBluesky