Yanhong Ge

This study identifies drugable pockets on c-MYC using simulations, showing 10074-G5 binds stably, offering a new approach to target this undruggable protein.

This paper investigates how temozolomide crosses brain plasma membranes using molecular dynamics simulations, finding that it cannot cross by pure diffusion at normal body temperature but requires higher temperatures or assistance from cholesterol and cerebroside lipids.