Mapping Alzheimer's neuropathology signatures to the whole brain transcriptome using machine learning data fusion
Anwesha Bhattacharya, Chloé Savignac, L. M. Hodgson…·Danilo Bzdok
Cell type-specific logistic regression estimators trained on 427 ROSMAP prefrontal donors project Braak- and β-amyloid-like transcriptomic signatures onto the 108-region Siletti atlas, flagging brainstem, hypothalamic and rostral hippocampal regions.