Elena Buscaroli

This paper introduces SCOUT, a synthetic whole-genome sequencing resource for benchmarking cancer genomic analysis, revealing performance issues in complex tumours and highlighting the importance of evolutionary ground truth.

BASCULE uses a Bayesian framework to standardize and cluster mutational signatures across cancer types, identifying prognostic subtypes in over 8,000 samples.

This paper introduces MOBSTERm, a Bayesian framework for subclonal deconvolution that accounts for spatio-temporal sampling biases in cancer sequencing data, improving the analysis of tumour evolution.