Zhun Shi

Genos-m is a foundation model for human-associated microbial genomes that outperforms existing models in gene-fitness prediction and community structure analysis.

The paper constructs a comprehensive gut microbiome reference database from Chinese and non-Chinese populations, revealing population-specific microbial features linked to host physiology.

This study identifies age-related sex differences in gut microbiota composition and functionality across two population cohorts, showing women have more diverse and stable microbiota than men, with sex differences diminishing in older adults.