Author

Colin M. Leaf

University of Southern CaliforniaORCID 0009-0001-9687-548XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Farzad Jalali‐YazdiiD· 1 shared Justin N. OngiD· 1 shared Pearl QiiD· 1 shared Rajiv K. KaliaiD· 1 shared Richard W. RobertsiD· 1 shared Terry T. TakahashiiD· 1 shared Yash GandhiiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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7 top collaborators · 21 mutual co-author links

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1 shared paperBioengineering

Farzad Jalali‐YazdiORCID

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1 paper

Recent·Most cited

Integrating Diffusion and Liquid AI Models for Predicting Peptide Affinity from mRNA Display Selections

Colin M. Leaf, Pearl Qi, Yash Gandhi, Farzad Jalali‐Yazdi, Justin N. Ong, Terry T. Takahashi, Rajiv K. Kalia, Richard W. Roberts

The paper predicts peptide binding affinities using machine learning models trained on mRNA display data, identifying high-affinity peptides with single-digit picomolar affinities.

bioRxiv · May 11, 2026 · PreprintBioengineering