Author

Richard W. Roberts

University of Southern CaliforniaORCID 0000-0002-8587-5097Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Terry T. TakahashiiD· 2 shared Anakha AjayaniD· 1 shared Anoop RawatiD· 1 shared Christopher HughesiD· 1 shared Colin M. LeafiD· 1 shared Farzad Jalali‐YazdiiD· 1 shared Hui XuiD· 1 shared Jeannie CheniD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBioengineering

Terry T. TakahashiORCID

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2 papers

Recent·Most cited

Integrating Diffusion and Liquid AI Models for Predicting Peptide Affinity from mRNA Display Selections

Colin M. Leaf, Pearl Qi, Yash Gandhi, Farzad Jalali‐Yazdi, Justin N. Ong, Terry T. Takahashi, Rajiv K. Kalia, Richard W. Roberts

The paper predicts peptide binding affinities using machine learning models trained on mRNA display data, identifying high-affinity peptides with single-digit picomolar affinities.

bioRxiv · May 11, 2026 · PreprintBioengineering

Protofibril Binding Peptides Recognize and Inhibit Huntingtin Amyloid Formation in vitro and in vivo

Kaori Noridomi, Jose Mario Isas, Anakha Ajayan, Tristan C. McPhail, Hui Xu, Anoop Rawat, Christopher Hughes, Natalie S. Chen, Joshua Lugo, Terry T. Takahashi, Jeannie Chen, Ralf Langen, Richard W. Roberts

This paper identifies peptides that bind and inhibit huntingtin protofibril formation in vitro and in vivo, offering potential diagnostic and therapeutic applications for Huntington's disease.

bioRxiv · Oct 21, 2025 · PreprintBiochemistry