Using a lanthanide tagged nanobody to visualise Glial fibrillary acidic protein by secondary ion mass spectrometry
Clara Dieterle, Siva Ramadurai, Matija Lagator, Lauren E.-A. Eyssen, Raymond J. Owens, Nicholas P. Lockyer, Hua Tian, Felicia M. Green
The paper demonstrates the use of lanthanide-tagged nanobodies for detecting GFAP in tissue via SIMS, showing compatibility with MSI and improved accessibility compared to conventional antibodies.
bioRxiv · Oct 23, 2026 · PreprintMolecular Biology