Raymond J. Owens

The paper demonstrates the use of lanthanide-tagged nanobodies for detecting GFAP in tissue via SIMS, showing compatibility with MSI and improved accessibility compared to conventional antibodies.

This study evaluates the pharmacokinetics, biodistribution, and therapeutic efficacy of a trimeric nanobody against SARS-CoV-2 in golden Syrian hamsters, showing that intranasal administration provides effective respiratory exposure and therapeutic benefit.

The paper uses cryo-electron tomography to study NiV fusion protein assemblies and shows nanobodies block inter-trimer interactions, inhibiting viral entry.

This study identifies two potent nanobodies targeting the conserved S2 region of SARS-CoV-2 spike protein that resist viral escape and reduce viral load in a hamster model.

This study shows that disrupting phage liquid crystalline droplets in Pseudomonas aeruginosa biofilms eliminates antibiotic tolerance by promoting antibiotic diffusion.

Alpha-BET uses AlphaFold to identify optimal sites for labeling viral glycoproteins with nanobodies, enabling high-resolution imaging of viral structures without disrupting their function.

The paper determines the crystal structures of unloaded and cargo-loaded VSR1-Nt, revealing two cargo binding sites and a calcium-dependent mechanism for cargo binding and release.

This study determines the structure of the GPC3-Unc5D complex and shows its role in guiding neuronal and cancer cell migration.

This study shows SARS-CoV-2 binding to ACE2 on pericytes enhances angiotensin II-induced cerebral capillary constriction via AT1 receptors, suggesting AT1 blockers may mitigate brain blood flow reduction in infection.