White matter reorganization of motor and affective-motivational networks in pain-indifferent carriers of the R221W mutation
Arnas Tamasauskas, Irene Perini, Jan Minde, Simon Sean Keller, Nicholas B. Fallon, Bernhard Frank, India Morrison, Andrew G. Marshall
The paper identifies structural and functional white matter changes in R221W mutation carriers, suggesting motor under-reactivity rather than sensory insensitivity in congenital insensitivity to pain.
bioRxiv · Jul 9, 2025 · PreprintNeuroscience