Andrew G. Marshall

This study investigates how force affects the pleasantness and intensity of stroking touch and the activity of C-LTMRs, finding that force modifies pleasantness and increases intensity with velocity.

The paper shows that TRPV1+ afferents rapidly reprogram TRPV1- Aβ afferents, leading to hyperalgesia in humans.

The paper identifies structural and functional white matter changes in R221W mutation carriers, suggesting motor under-reactivity rather than sensory insensitivity in congenital insensitivity to pain.

This study develops a method to sequence individual human DRG neuron somas, identifies 16 neuronal types, and reveals human-specific nociceptor types and potential drug targets.

The paper shows that SA-II and HFA afferents can distinguish social touch inputs with high accuracy using 3-4 seconds of firing data, outperforming other afferent types.

The paper compares mechanical pain discrimination between the hand and foot, finding the foot performs better, which cannot be explained by peripheral nociceptor activity.

The paper identifies PIEZO2-dependent mechanical pain in humans and mice, showing hair-pull pain is mediated by Aβ inputs and specific nociceptors.

Telomerecat estimates telomere length from whole-genome sequencing data without requiring prior knowledge of ploidy, showing good performance and detecting expected patterns in various data types.