Irene Perini

The paper identifies structural and functional white matter changes in R221W mutation carriers, suggesting motor under-reactivity rather than sensory insensitivity in congenital insensitivity to pain.

This study shows that 2-AG levels inversely correlate with fear generalization in both mice and humans, suggesting a role in fear discrimination.

This study investigates how congenital pain insensitivity in heterozygous humans and mice affects affective pain responses, finding dissociated effects on learned fear and neural processing.