Overglycosylation introduces local changes in triple helix alignment in collagen type I fibril structure
Luco Rutten, Judith M. Schaart, Liline A.S. Fermin, Jinge Xu, Marit A. de Beer, Robin H.M. van der Meijden, Karli R. Reiding, Anat Akiva, Nico A. J. M. Sommerdijk, Elena Macías‐Sánchez
This study shows that overglycosylation of collagen type I affects fibril structure by altering local packing and sub-band displacements without changing overall periodicity.
bioRxiv · Nov 9, 2025 · PreprintBiochemistry