In vivo affinity maturation of the HIV-1 Env-binding domain of CD4
Andi Pan, Charles C. Bailey, Tianling Ou, Jinge Xu, Tonia Aristotelous, Xin Liu, Baodan Hu, Gogce Crynen, Nickolas Skamangas, Naomi Bronkema, Mai H. Tran, Huihui Mou, Xia Zhang, Michael D. Alpert, Yiming Yin, , Wenhui He
This study demonstrates that non-antibody protein biologics can undergo affinity maturation in vivo, leading to improved binding affinity and neutralization potency against HIV-1.
bioRxiv · Feb 3, 2024Bioengineering