Lubricin's Mucin Domain Has Strong Polyproline Type-II Helical Character
Bibo ’Noah’ Feng, Ava J. Marks, Faith Mi Ge Kim, Mandar T. Naik, Tannin A. Schmidt, Khaled A. Elsaid, Gregory D. Jay, Brenda M. Rubenstein
This paper uses molecular dynamics simulations and circular dichroism experiments to show that lubricin's mucin domain has significant polyproline type II helical structure, stabilized by glycosylation.
Computational and Structural Biotechnology Journal · Mar 1, 2026Peer-reviewedBiophysics