Mandar T. Naik

This paper uses molecular dynamics simulations and circular dichroism experiments to show that lubricin's mucin domain has significant polyproline type II helical structure, stabilized by glycosylation.

The paper evaluates peptidomimetic inhibitors targeting TrkB/PSD-95 signaling in an Angelman Syndrome mouse model, showing improved seizure outcomes and cognition but not motor function.

This study investigates thiolutin's mode of action, showing it directly inhibits RNA Polymerase II in vitro but has complex in vivo effects involving oxidative stress and metal interactions.

The paper develops new cyclic compounds targeting the PSD-95 PDZ3 domain through structure-based design, achieving up to 7-fold stronger affinity than a prototype compound.