Pharmacology & ToxicologybioRxivPreprint
Tunable nucleofugality in carbamoyl-bearing covalent cholinesterase inhibitors
A. Meden, Damijan Knez, Xi Chen…·Stanislav Gobec
This study explores carbamoyl warhead reactivity in covalent cholinesterase inhibitors, identifying structure-reactivity relationships and demonstrating a highly selective, irreversible inhibitor.
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