Author

Manya Phutela

University of Massachusetts AmherstORCID 0009-0002-1156-5122Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:protein design· 1 Assay:protein sequence· 1 Approach:statistical model· 1

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Anna G. GreeniD· 1 shared Saishradha MohantyiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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1 shared paperBioinformatics

Anna G. GreenORCID

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1 paper

Recent·Most cited

BioinformaticsbioRxivPreprintSep 3, 2026

Towards Sparse Causal Features for Zero-shot Mutation Effect Prediction in a Protein Language Model

Saishradha Mohanty, Manya Phutela, Anna G. Green

The paper introduces a sparse feature circuit framework to identify causal features in ESM-2 for zero-shot mutation effect prediction, showing that shared circuits explain mutation effects through 3D contact residues.

DOI 10.64898/2026.08.28.747907

protein sequencestatistical model

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