Saishradha Mohanty

The paper introduces a sparse feature circuit framework to identify causal features in ESM-2 for zero-shot mutation effect prediction, showing that shared circuits explain mutation effects through 3D contact residues.

BIG-TB evaluates sequence-based machine learning models for predicting antibiotic resistance and variant attribution using *Mycobacterium tuberculosis* genomes, showing DNA-based models outperform protein-based ones.