ImmunologybioRxivPreprint
Exploiting HLA-II Promiscuity via Peptide Terminal Overhang Recognition for Pan-Allelic and Tumor-Selective AML Immunotherapy
Saori Fukao, Evey Y. F. Zheng, Fumie Ihara…·Naoto Hirano
This paper identifies an MPO-derived epitope promiscuously presented by HLA-II molecules and develops a pan-allelic antibody that selectively targets AML cells while sparing normal myeloid cells.
DOI 10.64898/2026.03.01.708866