Aberrant Hippo-YAP/TEAD signaling drives malignant transcriptional reprogramming in external auditory canal squamous cell carcinoma
Kuniaki Sato, Noritaka Komune, Mayumi Ono, Takahiro Hongo, Takafumi Nakano, Kensuke Koike, Shinsaku Itoyama, Kenichi Taguchi, Koshi Mimori, Jorge Silvio Gutkind, Muneyuki Masuda, Takashi Nakagawa
This study identifies hyperactivation of YAP/TEAD signaling in EACSCC and shows that targeting TEAD or PITX2 can suppress tumor growth and predict poor prognosis.
Cancer Research Communications · Jan 12, 2026Peer-reviewedCancer Biology