Kuniaki Sato

This study identifies a reversible GNAS-PKA-RUNX2 checkpoint that governs skeletal stem cell fate in fibrous dysplasia and shows PKA inhibition can reverse disease features.

This study identifies the COX2-PGE2-PKA axis as a negative regulator of mtDNA-STING signaling, which suppresses antiviral immunity by inhibiting STING activation through mitophagy.

This study identifies hyperactivation of YAP/TEAD signaling in EACSCC and shows that targeting TEAD or PITX2 can suppress tumor growth and predict poor prognosis.

The paper refines gene expression signatures using multi-omics data to improve enrichment analysis by addressing lack of coordinate expression in gene sets.