Experiment-guided AlphaFold3 resolves accurate protein ensembles
Advaith Maddipatla, Nadav Bojan Sellam, Meital Bojan, Volodymyr Masalitin, Sanketh Vedula, Paul Schanda, Ailie Marx, Alex M. Bronstein
This paper shows how AlphaFold3 can be guided by experimental data to predict accurate protein ensembles, including alternate conformations.
bioRxiv · Oct 11, 2025 · PreprintMolecular Biology