Paul Schanda

This paper uses integrated solid and solution NMR to study dynamics and ligand binding in a 134 kDa enzyme, revealing structural flexibility and substrate interactions.

The paper compares aromatic ring flip kinetics in GB1 protein across crystals, IgG complexes, and solution, showing reduced flipping in crystals and revealing how crystal environments restrain motion.

The paper identifies a dynamic displacement mechanism in mitochondrial protein import, showing that a flexible segment of Tom22 facilitates precursor protein release.

This paper shows how AlphaFold3 can be guided by experimental data to predict accurate protein ensembles, including alternate conformations.

The paper examines the dynamics of the yeast ADP/ATP transporter AAC3 in DPC detergent and finds that observed motions are not functionally relevant to its transport mechanism.