Author

Connor Siggins

Virginia TechORCID 0009-0002-3970-792XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Anthony‐Samuel LaMantiaiD· 2 shared Daniel W. MeechaniD· 2 shared Shah RukhiD· 2 shared Thomas Michael MaynardiD· 2 shared Zachary D. Erwin· 2 shared Abra Roberts· 1 shared Ashley Peck· 1 shared Gia Baldo· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 26 mutual co-author links

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2 shared papersNeuroscience

Anthony‐Samuel LaMantiaORCID

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2 papers

Recent·Most cited

Distinct cellular and transcriptional mechanisms mediate an antioxidant therapeutic response in 22q11-deleted upper layer cortical projection neurons

Shah Rukh, Daniel W. Meechan, Abra Roberts, Connor Siggins, Zachary D. Erwin, Thomas Michael Maynard, Anthony‐Samuel LaMantia

This study shows NAC treatment improves LgDel 22q11.2 deletion syndrome mouse cortical neurons' growth and connectivity without restoring wild-type gene expression or cell states.

bioRxiv · Dec 8, 2025 · PreprintNeuroscience

Transient disruption of progenitor states and layer 2/3 projection neuron generation in frontal association cortex due to 22q11.2 gene deletion

Shah Rukh, Daniel W. Meechan, Connor Siggins, Zachary D. Erwin, Gia Baldo, Ashley Peck, Thomas Michael Maynard, Anthony‐Samuel LaMantia

This study identifies transient disruptions in progenitor states and layer 2/3 neuron generation in the frontal cortex of a 22q11DS mouse model, linking these changes to schizophrenia risk.

bioRxiv · May 12, 2025 · PreprintNeuroscience