Systems BiologybioRxivPreprint
Mapping a genome-scale in vivo knockout screen to a mechanistic network model identifies VAV2, RASA1, and LEPR as regulators of cardiomyocyte hypertrophy
DOI 10.64898/2026.09.24.754086
Author
University of VirginiaORCID 0009-0002-4013-6394Unclaimed ORCID profile · follow to get notified of new preprints
2 papers
Recent·Most cited
Johane Bracamonte, Lionel D. Watkins, Betty Pat…·Jeffrey W. Holmes
This paper uses a Bayesian network model to analyze how mechanical loading and hormonal changes contribute to eccentric hypertrophy in volume overload, showing neurohormonal responses drive growth rather than initial stretch.