Xiaolong Guo

DNA methylation-based prediction of differentiation state at cell-type resolution reveals an age-associated epigenetic mesenchymal drift

This paper introduces EpiDiff, a DNA methylation-based tool to predict cell differentiation states, revealing age-related epigenetic drift in mesenchymal lineages and cancer risk associations.

OmniAge: a compendium of aging omic biomarkers links mitotic clocks to clonal hematopoiesis and causality

OmniAge compiles 413 aging biomarkers across 12 categories and reveals associations between mitotic clocks, clonal hematopoiesis, and cancer risk using blood datasets.

Optimizing effect sizes and specificity trumps machine learning when building DNA methylation reference panels for cell-type deconvolution

Unified high-resolution immune cell fraction estimation in blood tissue from birth to old age

The paper develops a DNAm reference panel called UniLIFE to estimate immune cell fractions in blood tissue across the lifespan, identifying biomarkers for type-1 diabetes in infants and children.

Epigenetic clocks and inflammaging: pitfalls caused by ignoring cell-type heterogeneity

The paper shows that an inflammation clock fails to capture inflammaging by not accounting for cell-type shifts, and is outperformed by a cell-type deconvolution method.

Cell-type specific epigenetic clocks to quantify biological age at cell-type resolution

The paper develops cell-type specific DNA methylation clocks to estimate biological age at cell-type resolution and finds they show age acceleration in disease states.