Macsue Jacques

The divergent effects of nicotinamide riboside and high-intensity exercise training on skeletal muscle epigenetic aging

This study examines how NR supplementation and HIIT affect skeletal muscle epigenetic aging, finding opposing effects on epigenetic age acceleration across different clocks.

CpG Atlas: A centralized multi-layer database and AI interface for DNA methylation research

CpG Atlas integrates over 1.2 million CpG sites across multiple methylation arrays with 18 annotation layers and provides a query interface for epigenetic research.

A Unified Framework for Systematic Curation and Evaluation of Aging Biomarkers

The paper develops Biolearn, an open-source framework for curating and evaluating aging biomarkers across datasets, finding that harmonization and standardization improve their performance and generalizability.

Sex-specific non-linear DNA methylation trajectories across aging predict cancer risk and systemic inflammation

DNA Methylation Ageing Atlas Across 17 Human Tissues

The paper creates a DNA methylation aging atlas across 17 human tissues, identifying conserved and tissue-specific aging signatures and potential therapeutic targets.

Cell-type specific epigenetic clocks to quantify biological age at cell-type resolution

The paper develops cell-type specific DNA methylation clocks to estimate biological age at cell-type resolution and finds they show age acceleration in disease states.

Molecular Landscape of Modality-Specific Exercise Adaptation in Human Skeletal Muscle through Large-Scale Multi-OMICs Integration

This study integrates multi-OMIC data from 12 cohorts to identify exercise-specific molecular signatures and gene regulatory patterns in human skeletal muscle.

Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle

This study shows exercise training reduces epigenetic and transcriptomic aging in human skeletal muscle, while muscle disuse accelerates transcriptomic aging.

DNA methylation and proteomics integration uncover dose-dependent group and individual responses to exercise in human skeletal muscle

This study integrates DNA methylation and proteomics data from human skeletal muscle to identify group and individual responses to high-intensity interval training.

Skeletal muscle methylome and transcriptome integration reveals profound sex differences related to muscle function and substrate metabolism

The paper integrates skeletal muscle methylome and transcriptome data across three cohorts to identify sex differences in DNA methylation and gene expression, revealing functional links between epigenetic and transcriptional sex biases.

Meta-analysis of genome-wide DNA methylation and integrative OMICs in human skeletal muscle.

The paper identifies age-related DNA methylation changes in human skeletal muscle through a meta-analysis and integrates these with transcriptomic and proteomic data, revealing enriched age-related gene expression patterns.

Identification of novel mitochondrial and mitochondrial related genetic loci associated with exercise response in the Gene SMART study

The paper identifies nine nuclear-encoded SNPs associated with exercise response in the Gene SMART cohort using whole-mitochondrial genome sequencing and composite trait analysis.