Lan Hu

The paper develops and validates a Disease Risk Score (DRS) framework using metatranscriptomics data to assess disease risk, showing significant risk enrichment for 15 diseases in an independent cohort.

This study shows the human gut microbiome remains stable in composition and function for up to six months, with resilience to short-term disruptions like colonoscopy preparation.

The paper develops gut microbial functional pathway scores from metatranscriptome data to identify molecular markers associated with irritable bowel syndrome and its subtypes.

The paper develops synthetic control samples for metatranscriptomic diagnostics, validated in a clinical lab with high reproducibility and signal strength.

The paper develops microbial functional pathway scores from metatranscriptomic data to assess oral health and disease phenotypes using saliva samples.