UFD1 Recognition of Initiator and Proximal Ubiquitin Drives p97-Mediated Substrate Unfolding enhanced by FAF1, FAF2, and UBXD7
Shunki Miyauchi, Ami Hirano, Nanako Yasumoto, Yuiha Goto, Yoshino Akizuki, Fumika Koyano, Tomoya Hino, Shingo Nagano, Noriyuki Matsuda, Fumiaki Ohtake, Gosuke Hayashi, Yusuke Sato
The paper elucidates how UFD1 recognizes initiator and proximal ubiquitin to drive p97-mediated substrate unfolding, with accessory adaptors enhancing this process.
bioRxiv · Mar 16, 2026 · PreprintBiochemistry