Xiang Yu

The paper identifies on-treatment biomarkers in TB patients by integrating immunomonitoring assays with PET/CT scans, showing significant cytokine changes and machine learning-based biomarkers for treatment response.

This paper introduces Transcript-Capture Seq to enrich bacterial mRNA from host samples, enabling analysis of the complete Mtb transcriptome in clinical samples and revealing gene expression patterns associated with in vivo bacterial activity.