Platform for Identifying Human Glycan-Specific Antibodies Against Bacterial Pathogens using Synthetic Glycan Fragments
A. Robin Temming, Mathieu A. F. Claireaux, Gius Kerster, Silvie E Groenewege, Thijs Voskuilen, Zhen Wang, Jeroen D. C. Codée, Marit J. van Gils, Nina M. van Sorge
This paper describes an experimental pipeline for generating human monoclonal antibodies against bacterial pathogens using synthetic glycan fragments, identifying functional antibodies against Staphylococcus aureus and Streptococcus pyogenes.
bioRxiv · Aug 19, 2025 · PreprintMicrobiology