High-Throughput Screening Reveals Potential Inhibitors Targeting Trimethoprim-Resistant DfrA1 Protein in Klebsiella pneumoniae and Escherichia coli
Soharth Hasnat, Soaibur Rahman, Meherun Binta Alam, Farha Mohi Suin, Farzana Yeasmin, Tanjila Suha, Nahuna Tanjin Supty, Sal Sabila, Animesh Chowdhury, ADA Shahinuzzaman, M Murshida Mahbub, M. Nazmul Hoque, Tofazzal Islam
This study identifies six potential inhibitors of the DfrA1 protein through high-throughput screening of 3,601 compounds, with DC4 and DC6 showing superior efficacy compared to the control drug.
bioRxiv · Nov 18, 2024 · PreprintBioinformatics