Author

Wei-Chia Chen

Cold Spring Harbor LaboratoryORCID 0009-0002-7064-1009Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:Bayesian inference· 2 Organism:bacteria (other)· 1 Assay:DNA methylation· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:imputation· 1 Research Focus:sequence-to-function modeling· 1

Frequent Co-Authors

David M. McCandlishiD· 2 shared Juannan ZhouiD· 2 shared Justin B. KinneyiD· 2 shared Arlin StoltzfusiD· 1 shared Carlos Martí‐GómeziD· 1 shared Jason M. SheltzeriD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

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6 top collaborators · 13 mutual co-author links

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2 shared papersEvolutionary Biology

David M. McCandlishORCID

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2 papers

Recent·Most cited

Evolutionary BiologybioRxivPreprintMar 9, 2025

✦ In-depth digest

Inference and visualization of complex genotype-phenotype maps with gpmap-tools

Carlos Martí‐Gómez, Juannan Zhou, Wei-Chia Chen…·David M. McCandlish

gpmap-tools uses Gaussian processes to infer and visualize genotype-phenotype maps with higher-order epistasis; across 262,144 Shine-Dalgarno variants it reveals register-specific peaks linked by three-nucleotide-offset ridges.

4 citations

E. colibacteria (other)

𝕏 PostBluesky

BioinformaticsbioRxivPreprintNov 25, 2020

Non-parametric Bayesian density estimation for biological sequence space with applications to pre-mRNA splicing and the karyotypic diversity of human cancer

Wei-Chia Chen, Juannan Zhou, Jason M. Sheltzer…·David M. McCandlish

The paper introduces a non-parametric Bayesian method for density estimation in sequence space and applies it to study pre-mRNA splicing and karyotypic diversity in human cancer.

DOI 10.1101/2020.11.25.399253

humanDNA methylation

𝕏 PostBluesky