Cancer BiologyNature CommunicationsPeer-reviewed
Quantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcoding
Frederick J.H. Whiting, Maximilian Mossner, Calum Gabbutt…·Trevor A. Graham
This paper develops a mathematical framework to infer cancer drug resistance dynamics from genetic lineage tracing and population size data, validated using experimental evolution and single-cell sequencing.