Frederick J.H. Whiting

This paper identifies cross resistance between cancer drugs using single-drug exposure data, showing that high cross resistance reduces the effectiveness of switching between CDK4/6 inhibitors.

This paper develops a mathematical framework to infer cancer drug resistance dynamics from genetic lineage tracing and population size data, validated using experimental evolution and single-cell sequencing.

This paper introduces dATAC, a single-cell multi-omic method for simultaneous whole genome sequencing and chromatin accessibility profiling, revealing genome-epigenome coevolution in colorectal cancer.