Christopher Kimberley

This paper develops a mathematical framework to infer cancer drug resistance dynamics from genetic lineage tracing and population size data, validated using experimental evolution and single-cell sequencing.

This study shows that immune evasion in colorectal cancer follows a 'Big Bang' pattern, where early genetic and epigenetic changes drive subsequent tumor-immune evolution.

The paper introduces rapidly oscillating molecular clocks to quantify human stem cell dynamics and finds differences in stem cell replacement rates between small intestine and colon, as well as effects of germline mutations.