Divergent RNA structures support accurate splicing of the SF3B1-sensitive MAP3K7 intron
Austin Herbert, Alexandra Randazza, Abigail Hatfield, Lela Lackey
The paper investigates how RNA sequence and structure influence splicing of the MAP3K7 intron, showing that branchpoint mutations strongly affect cryptic splice-site usage and that structural changes in RNA binding protein hotspots correlate with splicing outcomes.