Molecular BiologyNAR CancerPeer-reviewed
TDP 2 modulates the expression of estrogen-responsive oncogenes
Nicholas Manguso, Minhyung Kim, Neeraj Joshi…·Hisashi Tanaka
This study shows that TDP2 regulates estrogen-induced oncogene expression by resolving TOP2-induced DNA breaks, affecting MYC and CCND1 in ER-positive cells and mice.