Author

Nicholas Manguso

Cedars-Sinai Medical CenterORCID 0000-0002-2793-9996Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Armando E. GiulianoiD· 1 shared Felipe Cortés‐LedesmaiD· 1 shared Hisashi TanakaiD· 1 shared Juan AldacoiD· 1 shared Md Rasel Al MahmudiD· 1 shared Minhyung KimiD· 1 shared Neeraj Joshi· 1 shared Ryusuke SuzukiiD· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Armando E. GiulianoORCID

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1 paper

Recent·Most cited

TDP 2 modulates the expression of estrogen-responsive oncogenes

Nicholas Manguso, Minhyung Kim, Neeraj Joshi, Md Rasel Al Mahmud, Juan Aldaco, Ryusuke Suzuki, Felipe Cortés‐Ledesma, Xiaojiang Cui, Shintaro Yamada, Shunichi Takeda, Armando E. Giuliano, Sungyong You, Hisashi Tanaka

This study shows that TDP2 regulates estrogen-induced oncogene expression by resolving TOP2-induced DNA breaks, affecting MYC and CCND1 in ER-positive cells and mice.

NAR Cancer · Mar 15, 2024Peer-reviewedMolecular Biology