Felipe Cortés‐Ledesma

A comprehensive genetic catalog of human double-strand break repair

This study presents a comprehensive catalog of human double-strand break repair genes using genome-wide knockout data, revealing novel mechanisms and factors involved in DSB repair.

TAF1-dependent transcriptional dysregulation underlies multiple sclerosis

This study identifies TAF1-dependent transcriptional dysregulation as a mechanism underlying multiple sclerosis progression and presents an in vivo model for therapeutic development.

TDP 2 modulates the expression of estrogen-responsive oncogenes

This study shows that TDP2 regulates estrogen-induced oncogene expression by resolving TOP2-induced DNA breaks, affecting MYC and CCND1 in ER-positive cells and mice.

Topological regulation of the estrogen transcriptional response by ZATT-mediated inhibition of TOP2B activity

The paper identifies ZATT-mediated inhibition of TOP2B as a mechanism regulating estrogen-induced transcriptional changes through DNA supercoiling.

Genome-wide prediction of topoisomerase IIβ binding by architectural factors and chromatin accessibility

This paper predicts TOP2B binding sites using machine learning, showing that chromatin accessibility and architectural factors are sufficient for accurate predictions.

Control of RNA polymerase II promoter-proximal pausing by DNA supercoiling

The paper shows that topoisomerase IIa removes negative DNA supercoiling at promoters, repressing transcription by enforcing Pol II pausing, and reveals this as a novel regulatory mechanism for gene expression.