Kaiyuan Gao

FlexRibbon is a pretrained protein model that jointly learns from sequences and structures, achieving state-of-the-art performance in mutation-rich settings.

BioMiner automates extraction of protein-ligand bioactivity data from literature, achieving an F1 score of 0.32 and improving downstream model performance by 3.9%.

This paper develops a pre-trained antibody language model to improve CDR sequence and structure generation, outperforming previous methods in antigen-specific antibody design.