Jintao Zhu

CellChem: Cellular transcriptional responses reshape molecular representation space for efficient and multi-scale drug discovery

CellChem learns cell-guided molecular representations that integrate structure and function, improving drug discovery by capturing cellular response similarities.

Comparative assessment of co-folding methods for molecular glue ternary structure prediction

This paper evaluates co-folding methods for predicting ternary complexes involving molecular glues, finding AlphaFold3 performs best but relies on memorization rather than accurate modeling.

BioMiner: A Multi-modal System for Automated Mining of Protein-Ligand Bioactivity Data from Literature

BioMiner automates extraction of protein-ligand bioactivity data from literature, achieving an F1 score of 0.32 and improving downstream model performance by 3.9%.