Yuan Yuan

This study reports the atomic structure of mouse α-synuclein fibrils and shows they differ structurally and functionally from human fibrils linked to Parkinson's and MSA.

The paper identifies six novel α-synuclein fibril assemblies from cerebrospinal fluid samples and shows they have distinct functional properties despite no single structural feature predicting their function.

This paper applies targeted sequencing and haplotype analysis to develop a PGD assay for Usher syndrome, resulting in a successful pregnancy with a healthy baby.