Matched primary-metastasis single-nucleus and spatial profiling of leiomyosarcoma identifies antigen-presenting fibroblasts at the tumor-organ interface
Anna Kübler, Linda Bergmayr, Thomas Knösel, Philipp Sebastian Jurmeister, Yauheniya Zhdanovich, Luc M. Berclaz, Josephine Deleuran Hendriksen, Dilara Karaoğlu, Romy L. Zuber, Michael Hoberger, Dorit Di Gioia, Markus Albertsmeier, Matthias Grube, Martin Trepel, Carolin Mogler, , Andreas Möck
This study uses single-nucleus RNA sequencing and spatial transcriptomics to compare primary and metastatic leiomyosarcoma, identifying antigen-presenting fibroblasts associated with metastasis.
bioRxiv · Oct 5, 2026 · PreprintCancer Biology