Author

Huisheng Zhu

Stanford UniversityORCID 0009-0003-0639-7002Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Evolutionary Biology· 1 Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:GWAS summary statistics· 2 Research Focus:gene regulatory network inference· 1 Research Focus:GWAS / association mapping· 1 Research Focus:polygenic risk· 1

Frequent Co-Authors

Jeffrey P. SpenceiD· 3 shared Jonathan K. PritchardiD· 3 shared Yuval B. SimonsiD· 2 shared Clemens L. WeißiD· 1 shared Courtney J. SmithiD· 1 shared Guy SellaiD· 1 shared Hakhamanesh MostafaviiD· 1 shared Nikhil MilindiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersEvolutionary Biology

Jeffrey P. SpenceORCID

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3 papers

Recent·Most cited

Evolutionary BiologyProceedings of the National Academy of SciencesPeer-reviewedSep 1, 2026

Genetic architectures of brain-related traits are shaped by strong selective constraints

Huisheng Zhu, Yuval B. Simons, Jeffrey P. Spence…·Jonathan K. Pritchard

The paper compares genetic architectures of brain-related traits and finds they have weaker associations and stronger selection pressures compared to other traits.

2 citationstop 3%

humanGWAS summary statistics

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintNov 11, 2024

Buffering and non-monotonic behavior of gene dosage response curves for human complex traits

Nikhil Milind, Courtney J. Smith, Huisheng Zhu…·Jonathan K. Pritchard

The paper analyzes gene dosage response curves for human complex traits and shows that they exhibit biased direction of effect, developing a theoretical model to explain this phenomenon.

15 citations

humanstatistical model

𝕏 PostBluesky

GeneticsbioRxivPreprintJun 15, 2024

Conditional frequency spectra as a tool for studying selection on complex traits in biobanks

Roshni A. Patel, Clemens L. Weiß, Huisheng Zhu…·Jonathan K. Pritchard

The paper introduces conditional frequency spectra to study selection on complex traits in biobanks, finding evidence for stabilizing or purifying selection on GWAS-associated variants.

8 citations

humanGWAS summary statistics

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