Clemens L. Weiß

PATH-IC uses generative AI to predict breast cancer genomic subtypes from histology images, achieving high accuracy and correlating with clinical outcomes.

ecDNAInspector identifies high-confidence ecDNA structures from WGS data, linking them to clinical and molecular features in breast cancer.

This study shows that many premalignant colorectal polyps contain multiple genetic lineages, indicating polyclonal origins rather than single-cell expansion.

The paper predicts significant future genetic diversity losses even with habitat protection using a spatio-temporal framework calibrated with genomic data from 29 species.

The paper introduces conditional frequency spectra to study selection on complex traits in biobanks, finding evidence for stabilizing or purifying selection on GWAS-associated variants.

This study analyzes ancient DNA from 204 individuals to show stable population structure in Europe despite high mobility during the historical period.

This study analyzes ancient genomes from the Iron Age central Mediterranean to explore population continuity and mobility, finding significant local contributions and diverse non-local ancestries.

The paper develops a method to enrich for damaged DNA molecules in ancient samples to better identify authentic microbial taxa.

nQuire estimates ploidy (diploid, triploid, tetraploid) using NGS data with a Gaussian Mixture Model and maximum likelihood.