Yikai Dong

This study shows that rare variant burden adds information beyond polygenic risk scores for breast cancer and is more strongly associated with earlier diagnosis.

This study identifies centromeric structural variants linked to molecular traits and complex diseases in humans using long-read sequencing and haplotype-resolved analysis.

This paper identifies shared genetic and neuroimmune mechanisms linking type 1 diabetes with neurocognitive traits through genome-wide association and single-cell epigenomic analyses.

MIXPRS improves multi-population polygenic risk score prediction by integrating GWAS summary statistics without individual-level data, outperforming existing methods across multiple traits and populations.

JointPRS improves genetic risk prediction for non-European populations by integrating genetic correlation and multi-population data without individual-level tuning data.